Cancer Chemosensitivity Testing: Review

Cancer Chemosensitivity Testing: Review

Since chemotherapy started in 1940s, chemosensitivity testing has been both a very attractive field and one fraught with potential pitfalls. Many methods were developed and brought initial promises, yet later ending in disappointment and were eliminated. For example, in the 1970s clonogenic assay was generally believed to be the best testing method for predicting clinical outcome. However, tech...

Challenges of chemosensitivity testing.

One of the major goals in cancer therapeutics is to increase efficacy and reduce toxicity by tailoring therapy to individual patients. It is well known that tumors and patients are heterogeneous, and with every therapeutic approach, whether immunotherapy, chemotherapy, or antivascular strategy, patient response can be extremely variable, ranging from progression to complete responses. Understan...

Chemosensitivity testing: another chapter.

In vitro chemosensitivity testing of anticancer agents for patient treatment has evolved gradually since the time of our report in 1978 (7) on the use of a human tumor cloning or tumor stem cell assay for this purpose. Although some technical problems remain, definite improvement has been seen in the frequency of in vitro sensitivity results with several assay systems {2-4). One important quest...

[Chemosensitivity testing in ovarian cancer--prospects for the future].

Individualization of treatment on the basis of in vitro chemosensitivity testing constitutes one of the aims of contemporary oncology Although previous studies report advantages resulting from chemosensitivity laboratory tests, the issue remains an area of interest. The aim of this study was to discuss chemosensitivity assay methods of ovarian cancer cells. ATP-TCA (ATP-based tumor chemosensiti...

Chemosensitivity in Breast Cancer